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An oligonucleotide of at least 12 nucleotides complementary to a sequence uniquely present in the nucleic acid of any of claims 1 to 4. The oligonucleotide of claim 5 which is at least 15 or 16 nucleotides in length. The oligonucleotide of claims 5 or 6, wherein the oligonucleotide is detectably labeled.
The oligonucleotide of claim 7, wherein the detectable label comprises a radioisotope, a fluorophore, or biotin. The oligonucleotide of any of claims 5 to 8, wherein the oligonucleotide is selectively methylated. A vector comprising the nucleic acid molecule of any of claims 1 to 4.
The vector of claims 10 or 11, comprising a promoter operably linked to the nucleic acid molecule. A host cell which comprises a vector of any of claims 10 to The host cell of claim 13, wherein said host cell is a eukaryotic or a prokaryotic cell.
The host cell of claim 14, wherein said host cell is selected from the group consisting of: The feline CD86 ligand polypeptide or feline CD86 soluble ligand polypeptide encoded by the nucleic acid molecule of any of claim to 4.
A method of producing the polypeptide of claim 16 which comprises culturing a host cell which expresses the polypeptide and recovering the polypeptide so produced. A vaccine composition comprising an effective amount of a polypeptide of claim 16 and a suitable carrier.
The vaccine of claim 18, wherein the effective amount is an amount from about 0. The vaccine of any one of claims 18 to 20 which further Is589 wk4 mini case central university an immunogen derived from a pathogen.
The vaccine of claim 21, wherein the pathogen is a feline pathogen, a rabies virus, chlamydia, Toxoplasmosis gondii, Dirofilaria immitis, a flea, or a bacterial pathogen.
The vaccine of claim 22, wherein the feline pathogen is feline immunodeficiency virus FIVfeline leukemia virus FeLVfeline infectious peritonitis virus MPfeline panleukopenia virus, feline calicivirus, feline reovirus type 3, feline rotavirus, feline coronavirus, feline syncytial virus, feline sarcoma virus, feline herpesvirus, feline Borna disease virus, or a feline parasite.
Use of a vaccine of any of claims 18 to 23 for the preparation of a pharmaceutical composition for inducing immunity in a feline. Use of a vaccine of any of claims 18 to 23 for the preparation of a pharmaceutical composition for enhancing an immune response in a feline.
The use of claims 24 or 25, wherein the vaccine is administered subcutaneously, intramuscularly, systemically, topically, or orally. Use of an effective amount of a polypeptide of claim 18 or a polypeptide resulting from the method of claim 19 for the preparation of a pharmaceutical composition for suppressing an immune response in a feline.
The use of claim 27, wherein the amount is from about 0. The use of claim 27 or 28, wherein the feline is suffering from an autoimmune disease or is the recipient of a tissue or organ transplant. Use of a nucleic acid which hybridizes to a feline CD86 ligand mRNA transcript encoded by the nucleic acid of claims and which inhibits the translation of said mRNA for the preparation of a pharmaceutical composition for suppressing an immune response in a feline.
Current feline leukemia virus vaccines are available, but their level of efficacy remains questionable and in some cases may cause the disease. Therefore, there is a need in the art for agents and compositions that provide protection from these and other diseases where there is not yet an existing vaccine or that improve the efficacy of existing and commonly used vaccines.
In addition, vaccination of kittens is difficult due to inability to overcome maternal antibodies in kittens. Safe and effective agents to help overcome these barriers are also needed. The stimulation of T-cell activation and proliferation in response to disease in the host is believed to be dependent on two interactions: In the absence of adequate co-stimulation of T-cells, an anergic state may develop, whereby T cells fail to proliferate and secrete cytokines.
CD28 is the primary T-cell co-stimulatory receptor and upon interaction with CD80 and CD86, it enhances T-cell proliferation and cytokine synthesis, preventing T-cell death.
Although, not completely understood, it appears to inhibit T-cell costimulatory responses. The interaction and interplay among CD28, CTLA-4 and their ligands CD80 and CD86 in co-stimulatory processes is key to the overall induction and suppression of immune responses to disease in the host.
By manipulating the expression of these 4 costimulatory molecules, it may be possible to regulate T-cell responses, through augmentation, suppression or redirection, to raise a desired immune response towards a particular pathogen or disease condition.
In particular, they may be useful for vaccination against infectious diseases, treatment of infectious diseases, and treatment of neoplastic, degenerative, autoimmune, and immunodeficiency conditions. T-lymphocytes of the mammalian immune system display both control and effector functions.
T cell progenitors arise in the bone marrow from stem cells and migrate to the thymus. In the thymus, maturation and selection take place to produce a naive population of immune cells that is able to recognize antigen in the context of major histocompatibility complex MHC presentation but is not autoreactive.
Following thymic maturation, each T cell possesses a clonally distributed T cell receptor TCR which determines its antigen specificity.
Protein and gene organization of the TCR protein is similar to that observed with immunoglobulin Ig molecules, and it shares many properties similar to membrane bound Ig on B cells Allison and Lanier, Like the Ig molecule, the TCR must potentially recognize a vast number of potential antigen sequences.
For this reason, TCR gene organization and rearrangement is similar in complexity with that observed in B cells Davis and Bjorkman, Unlike B cells however, T-cells do not appear to generate diversity through somatic mutation, though the potential repertoire of the TCR appears to be as great as that of the Ig molecule Lechler et al.View Notes - Central University Minicase Week 4 from MISM IS at DeVry University, Keller Graduate School of Management.
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The university has 10 separate colleges (e.g., business, arts, journalism), 3 of which are relatively large ( faculty and staff members.
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